San Francisco 49ers vs. Buffalo Bills Same Game Parlay Picks, Odds & Predictions

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Published by Mike Rose on November 28, 2024

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The Week 13 installment of Sunday Night Football takes NFL bettors to Highmark Stadium where the Buffalo Bills will return from the bye looking to pick right back up where they left off against a bruised and battered San Francisco 49ers out that may or may not be without the services of Brock Purdy and Nick Bosa. It’s tough to come up with an official handicap of the NFL odds not knowing the availability of each player at the time of this writing. With that, I’ll recommend positions to take on the side and total with the belief each is deemed healthy enough to take the field Sunday night. PROLINE+ opened the this SNF matchup with the Bills only laying 3.5-points and the total lined 47. With each aforementioned player missing the Niners last week’s ugly showing on the “Frozen Tundra,” and it unknown as to whether each will play in this one, the number to beat has shot up to 7 and the total down to 44.

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San Francisco 49ers vs. Buffalo Bills NFL Same Game Parlay:

It’s been a rough go of it for the 49ers over the last month-plus with it 2-3 SU and the pair of wins coming against two sub .500 opponents in the Buccaneers and Cowboys. The three defeats came against the playoff bound Chiefs and Packers as well as a Seahawks squad that just took over the division lead after toppling the Cardinals at home. Even with Christian McCaffrey, George Kittle, and Deebo Samuel in the mix at Green Bay last week, the Packers had absolutely no issue shutting the Niners offense down with Brandon Allen at the helm. The kid played to a 76.7 QB rating even though he threw for 199 yards and a score. The interception and fumble had much to do with it. That’s how important it is for Brock Purdy to be under center for this offense. That being said, just how healthy is the Niners QB1 and just how long would he hold up if attempting to play through the shoulder injury on a frigid night in Buffalo with the BillsMafia making it that much tougher to succeed? Though it’s believed Trent Williams will give it a go, is he truly healthy or just pushing it. If everyone was healthy, I’d have no issue grabbing the points with the Niners. But they aren’t so I won’t recommend it.

By no means am I 100 percent sold on this Buffalo Bills team. Though 9-2 and moneymaking 7-4 against the closing NFL spread, I keep waiting for the other shoe to drop. So far, Sean McDermott and his staff have pushed all the right buttons propelling the team to the No. 2 seed in the AFC. This stretch right out of the bye represents their toughest the remainder of the NFL betting season. After this game, they got back-to-back road trips scheduled for Los Angeles and Detroit to run with the Rams and Lions. After that, it’s two with the Patriots—both home and away—as well as a home tilt against a Jets team I can’t help but think will have closed shop by then. With that, the top overall seed will be there for the taking and I fully expect Buffalo to bring everything they’ve got to close things out. On top of that, the team got healthier during the break with it expected both Keon Coleman and Dalton Kincaid will be back in the offensive huddle. The defense got some great news as well with stud LB Matt Milano practicing in full and expected back on the field Sunday night.

We should’ve swept last week’s same-game parlay involving the 49ers last week against the Packers. That game had absolutely no business going over the total! As it is, whether Purdy and Bosa play or not, I’m laying the home chalk with the Bills and fully expect Josh Allen and his mates to treat this like a business trip before moving onto the next opponent. Get in, do your thing, and get out. That should be the M.O. right from the jump with the injury-riddled 49ers simply just not up to snuff due to the injury bug ransacking the roster. They’ll no doubt take the field angry, but Buffalo is yet to be ousted in its home digs and I truly don’t know if San Fran’s pieces are really healthy or just being pushed to get into the huddle. Lay the points and hit that under!